What it is: A small protein based on one of your body's own healing hormones. It targets a specific 'repair
switch' in damaged tissue that turns down inflammation and helps regrow injured nerve fibers — without
affecting red blood cells.
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Clinical trial results: In a 64-patient double-blind study, patients with nerve damage showed measurable
regrowth of nerve fibers — not just less pain, but actual structural repair. Pain scores dropped roughly 40% vs
placebo.
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Functional gains: Patients walked significantly farther on a 6-minute walk test. One patient said: "I went to the
mall all afternoon — I haven't been able to do that in years."

Why it matters here: Small fiber nerve damage is now recognized as a key driver of Long COVID, POTS,
CRPS, and ME/CFS fatigue. ARA-290 is one of the only compounds shown to actually repair those nerves.
Safety: No serious side effects across any trial. No blood changes. Self-administered as a small injection under
the skin — similar to insulin.

Nerve Repair Long COVID CRPS POTS ME/CFS Phase II ✓

What it is: A peptide your thymus gland naturally makes to train and regulate your immune system. Think of it as a reset button for an immune system that's stuck in overdrive — or burned out and unable to do its job.

- Addresses immune burnout: In Long COVID and ME/CFS, immune cells become 'exhausted' and can't
function properly. Studies show Thymosin Alpha-1 can wake those cells back up and restore normal balance.

- Long COVID data: Lab studies using blood from Long COVID patients showed it reversed the specific immune
abnormalities caused by COVID — including the T-cell problems driving ongoing symptoms.

- COVID survival data: A pooled analysis of 8 studies found patients who received it had a 41% lower risk of
dying from COVID compared to those who did not.

- Safety: One of the most studied peptides that exists. Used clinically in Asia for decades. Only minor
injection-site reactions across 11,000+ patients in 30+ trials.

Immune Reset Long COVID ME/CFS MCAS 30+ Trials ✓

What it is: One of your body's natural anti-inflammatory messengers, found in your brain, gut, lungs, and
immune cells. In people with MCAS, POTS, and Long COVID, VIP levels are often very low — and replacing
it can have wide-ranging effects.

Calms overactive mast cells: In MCAS, mast cells fire constantly and cause widespread reactions. VIP shifts
them into a calmer, less reactive state — working differently from antihistamines, which only block the damage
after it's done.

Helps POTS & dysautonomia: VIP relaxes blood vessels and reduces nervous system inflammation — two of
the main problems driving the dizziness, racing heart, and fatigue of autonomic dysfunction.

Real-world use: Used as a nasal spray in 10,000+ patients with chronic inflammatory illness. Documented
improvements in brain fog, fatigue, shortness of breath, and day-to-day function.

Safety: Can lower blood pressure, so it's monitored carefully. Used safely in clinical practice for 15+ years. FDA
Fast Track granted for COVID-related lung failure.

MCAS POTS Dysautonomia Long COVID ME/CFS FDA Fast Track ✓

What it is: A molecule every single cell in your body needs to produce energy. Think of it as the fuel your
cellular engines run on. In Long COVID and ME/CFS, those engines are damaged — and NAD+ levels are
significantly depleted.

2025 clinical trial: A randomized controlled trial (Mass General Brigham, 2025) found that boosting NAD+
improved fatigue and brain fog in Long COVID patients after 10+ weeks of treatment.

Combination therapy: A 2024 pilot study pairing NAD+ with low-dose naltrexone found significant
quality-of-life improvements in people with persistent post-COVID fatigue over 12 weeks.

Why these patients are so tired: Muscle biopsies from Long COVID patients confirm that the machinery for
making cellular energy is physically damaged. NAD+ helps repair and refuel it.

Safety: NAD+ is a naturally occurring molecule your body already makes. IV and intranasal delivery provide
faster, more complete absorption than oral supplements alone.

Long COVID ME/CFS Fatigue Brain Fog 2025 RCT ✓

What it is: A well-known FDA-approved medication — used clinically for over a century — that has a
remarkable ability to rescue cells when their normal energy-making process is damaged or stuck.

How it helps: In Long COVID and ME/CFS, the cellular energy system gets stuck at a damaged step.
Methylene Blue acts like a detour road — it skips the damaged part and keeps energy production going. Many
patients report improvements in fatigue and mental clarity.

Brain fog: It crosses into the brain and reduces inflammation where it's needed. Studies show it protects brain
cells and improves how they use oxygen.

Antiviral properties: In laboratory studies, Methylene Blue inhibited COVID-19 replication — relevant if
persistent viral fragments are contributing to ongoing symptoms.
Important safety note: Only pharmaceutical-grade (USP) should be used — online versions can contain heavy
metal contaminants. Cannot be combined with antidepressants. Physician supervision is essential.

Long COVID ME/CFS Brain Fog Fatigue FDA-Approved ✓